MAPK1
Entrez ID: 5594
Full name: mitogen-activated protein kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: ERK1
Chromosomal location: 22q11.22
Substructure location: Gatekeeper: 110 A-loop: 166...192 G-loop: 32...39 αC-helix: 62...77
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MAPK1
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending...
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
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GO - Biological processes (BP):
activation of MAPK activity, activation of MAPKK activity, aging, apoptotic process, axon guidance, B cell receptor signaling pathway, Bergmann glial cell differentiation, cardiac neural crest cell development involved in heart development, caveolin-mediated endocytosis, cell cycle, cell surface rec...
activation of MAPK activity, activation of MAPKK activity, aging, apoptotic process, axon guidance, B cell receptor signaling pathway, Bergmann glial cell differentiation, cardiac neural crest cell development involved in heart development, caveolin-mediated endocytosis, cell cycle, cell surface receptor signaling pathway, cellular response to amino acid starvation, cellular response to cadmium ion, cellular response to DNA damage stimulus, cellular response to dopamine, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to organic substance, cellular response to reactive oxygen species, cellular response to tumor necrosis factor, chemical synaptic transmission, chemotaxis, cytosine metabolic process, decidualization, diadenosine tetraphosphate biosynthetic process, ERBB signaling pathway, ERK1 and ERK2 cascade, face development, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, fibroblast growth factor receptor signaling pathway, intracellular signal transduction, labyrinthine layer blood vessel development, learning or memory, lipopolysaccharide-mediated signaling pathway, long-term synaptic potentiation, lung morphogenesis, mammary gland epithelial cell proliferation, MAPK cascade, negative regulation of cell differentiation, neutrophil degranulation, outer ear morphogenesis, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, platelet activation, positive regulation of cardiac muscle cell proliferation, positive regulation of cell migration, positive regulation of gene expression, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein import into nucleus, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, positive regulation of transcription, DNA-templated, positive regulation of translation, protein phosphorylation, regulation of cellular pH, regulation of cellular response to heat, regulation of cytoskeleton organization, regulation of DNA-binding transcription factor activity, regulation of early endosome to late endosome transport, regulation of gene expression, regulation of Golgi inheritance, regulation of ossification, regulation of phosphatidylinositol 3-kinase signaling, regulation of protein stability, regulation of stress-activated MAPK cascade, response to epidermal growth factor, response to estrogen, response to exogenous dsRNA, response to nicotine, sensory perception of pain, signal transduction, stress-activated MAPK cascade, T cell receptor signaling pathway, thymus development, thyroid gland development, trachea formation, viral process
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GO - Molecular function (MF):
ATP binding, double-stranded DNA binding, identical protein binding, kinase activity, MAP kinase activity, MAP kinase kinase activity, mitogen-activated protein kinase kinase kinase binding, phosphatase binding, phosphotyrosine residue binding, protein serine/threonine kinase activity, RNA polymeras...
ATP binding, double-stranded DNA binding, identical protein binding, kinase activity, MAP kinase activity, MAP kinase kinase activity, mitogen-activated protein kinase kinase kinase binding, phosphatase binding, phosphotyrosine residue binding, protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription factor binding
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GO - Cellular component (CC):
cytoskeleton, microtubule organizing center, mitotic spindle, cytosol, early endosome, late endosome, extracellular region, Golgi apparatus, azurophil granule lumen, mitochondrion, nucleoplasm, nucleus, caveola, plasma membrane, axon, cell, cytoplasm, dendrite cytoplasm, ficolin-1-rich granule lumen...
cytoskeleton, microtubule organizing center, mitotic spindle, cytosol, early endosome, late endosome, extracellular region, Golgi apparatus, azurophil granule lumen, mitochondrion, nucleoplasm, nucleus, caveola, plasma membrane, axon, cell, cytoplasm, dendrite cytoplasm, ficolin-1-rich granule lumen, focal adhesion, perikaryon, postsynaptic density, protein-containing complex, pseudopodium
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mitogen-activated protein kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc