EPHA2
Entrez ID: 1969
Full name: EPH receptor A2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 1p36.13
Substructure location: Gatekeeper: 692 A-loop: 756...782 G-loop: 619...625 αC-helix: 635...637
Please click HERE
for better display.
EPHA2
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling ...
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
View more >>
GO - Biological processes (BP):
activation of GTPase activity, axial mesoderm formation, axon guidance, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, cAMP metabolic process, cell adhesion, cell chemotaxis, cell migration, cel...
activation of GTPase activity, axial mesoderm formation, axon guidance, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, cAMP metabolic process, cell adhesion, cell chemotaxis, cell migration, cell motility, defense response to Gram-positive bacterium, ephrin receptor signaling pathway, inflammatory response, intrinsic apoptotic signaling pathway in response to DNA damage, keratinocyte differentiation, lens fiber cell morphogenesis, mammary gland epithelial cell proliferation, multicellular organism development, negative regulation of angiogenesis, negative regulation of chemokine production, negative regulation of lymphangiogenesis, negative regulation of protein kinase B signaling, neural tube development, notochord cell development, notochord formation, osteoblast differentiation, osteoclast differentiation, pericyte cell differentiation, positive regulation of bicellular tight junction assembly, positive regulation of kinase activity, positive regulation of protein localization to plasma membrane, post-anal tail morphogenesis, protein kinase B signaling, protein localization to plasma membrane, regulation of angiogenesis, regulation of blood vessel endothelial cell migration, regulation of cell adhesion mediated by integrin, regulation of ERK1 and ERK2 cascade, regulation of lamellipodium assembly, response to growth factor, skeletal system development, transmembrane receptor protein tyrosine kinase signaling pathway, vasculogenesis
View more >>
GO - Molecular function (MF):
ATP binding, cadherin binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity...
ATP binding, cadherin binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity
View more >>
GO - Cellular component (CC):
integral component of plasma membrane, lamellipodium membrane, leading edge membrane, plasma membrane, ruffle membrane, cell surface, focal adhesion, lamellipodium, neuron projection, receptor complex, tight junction...
integral component of plasma membrane, lamellipodium membrane, leading edge membrane, plasma membrane, ruffle membrane, cell surface, focal adhesion, lamellipodium, neuron projection, receptor complex, tight junction
View more >>
EPH receptor A2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for EPHA2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc