EPHA3
Entrez ID: 2042
Full name: EPH receptor A3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 3p11.1
Substructure location: Gatekeeper: 699 A-loop: 763...789 G-loop: 627...633 αC-helix: 661...674
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EPHA3
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pa...
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
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GO - Biological processes (BP):
axon guidance, cell adhesion, cell migration, cellular response to retinoic acid, ephrin receptor signaling pathway, fasciculation of motor neuron axon, fasciculation of sensory neuron axon, multicellular organism development, negative regulation of endocytosis, peptidyl-tyrosine phosphorylation, po...
axon guidance, cell adhesion, cell migration, cellular response to retinoic acid, ephrin receptor signaling pathway, fasciculation of motor neuron axon, fasciculation of sensory neuron axon, multicellular organism development, negative regulation of endocytosis, peptidyl-tyrosine phosphorylation, positive regulation of kinase activity, positive regulation of neuron projection development, positive regulation of protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of epithelial to mesenchymal transition, regulation of focal adhesion assembly, regulation of GTPase activity, regulation of microtubule cytoskeleton organization, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
actin cytoskeleton, cytosol, early endosome, extracellular region, nuclear membrane, nucleoplasm, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex...
actin cytoskeleton, cytosol, early endosome, extracellular region, nuclear membrane, nucleoplasm, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex
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EPH receptor A3
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Kaplan plot for EPHA3 in
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*NOTE: the Kaplan plots were collected from OncoLnc