EPHA8
Entrez ID: 2046
Full name: EPH receptor A8
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 1p36.12
Substructure location: Gatekeeper: 713 A-loop: 777...803 G-loop: 641...649 αC-helix: 675...688
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EPHA8
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pa...
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
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GO - Biological processes (BP):
axon guidance, cell adhesion, cellular response to follicle-stimulating hormone stimulus, ephrin receptor signaling pathway, multicellular organism development, neuron projection development, neuron remodeling, positive regulation of kinase activity, positive regulation of MAPK cascade, positive reg...
axon guidance, cell adhesion, cellular response to follicle-stimulating hormone stimulus, ephrin receptor signaling pathway, multicellular organism development, neuron projection development, neuron remodeling, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of phosphatidylinositol 3-kinase activity, protein autophosphorylation, regulation of cell adhesion, regulation of cell adhesion mediated by integrin, substrate-dependent cell migration, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
early endosome membrane, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex...
early endosome membrane, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex
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EPH receptor A8
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Kaplan plot for EPHA8 in
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*NOTE: the Kaplan plots were collected from OncoLnc