EPHB2
Entrez ID: 2048
Full name: EPH receptor B2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 1p36.12
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 624...637 αC-helix: 661...674
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EPHB2
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling p...
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874).
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GO - Biological processes (BP):
angiogenesis, axonal fasciculation, axon guidance, camera-type eye morphogenesis, central nervous system projection neuron axonogenesis, commissural neuron axon guidance, corpus callosum development, dendritic spine development, dendritic spine morphogenesis, ephrin receptor signaling pathway, inact...
angiogenesis, axonal fasciculation, axon guidance, camera-type eye morphogenesis, central nervous system projection neuron axonogenesis, commissural neuron axon guidance, corpus callosum development, dendritic spine development, dendritic spine morphogenesis, ephrin receptor signaling pathway, inactivation of MAPKK activity, inner ear morphogenesis, learning, learning or memory, multicellular organism development, negative regulation of axonogenesis, negative regulation of ERK1 and ERK2 cascade, negative regulation of NMDA glutamate receptor activity, negative regulation of protein phosphorylation, negative regulation of Ras protein signal transduction, nervous system development, neuron projection retraction, optic nerve morphogenesis, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of long-term neuronal synaptic plasticity, positive regulation of long-term synaptic potentiation, positive regulation of NMDA glutamate receptor activity, positive regulation of protein localization to plasma membrane, positive regulation of synapse assembly, positive regulation of synaptic plasticity, postsynaptic membrane assembly, regulation of blood coagulation, regulation of body fluid levels, regulation of neuronal synaptic plasticity, retinal ganglion cell axon guidance, roof of mouth development, transmembrane receptor protein tyrosine kinase signaling pathway, trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission, urogenital system development
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GO - Molecular function (MF):
amyloid-beta binding, ATP binding, axon guidance receptor activity, identical protein binding, protein-containing complex binding, protein tyrosine kinase activity, signaling receptor binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
amyloid-beta binding, ATP binding, axon guidance receptor activity, identical protein binding, protein-containing complex binding, protein tyrosine kinase activity, signaling receptor binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular region, nucleoplasm, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, plasma membrane, axon, dendrite, glutamatergic synapse, neuronal cell body, postsynapse, receptor complex...
cytosol, extracellular region, nucleoplasm, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, plasma membrane, axon, dendrite, glutamatergic synapse, neuronal cell body, postsynapse, receptor complex
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EPH receptor B2
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Kaplan plot for EPHB2 in
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*NOTE: the Kaplan plots were collected from OncoLnc