LTK
Entrez ID: 4058
Full name: leukocyte receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: ALK
Chromosomal location: 15q15.1
Substructure location: Gatekeeper: 590 A-loop: 663...688 G-loop: [N/A] αC-helix: [N/A]
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LTK
Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically...
Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
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GO - Biological processes (BP):
cell population proliferation, cellular response to retinoic acid, multicellular organism development, negative regulation of apoptotic process, phosphatidylinositol 3-kinase signaling, positive regulation of cardiac muscle cell apoptotic process, positive regulation of kinase activity, positive reg...
cell population proliferation, cellular response to retinoic acid, multicellular organism development, negative regulation of apoptotic process, phosphatidylinositol 3-kinase signaling, positive regulation of cardiac muscle cell apoptotic process, positive regulation of kinase activity, positive regulation of neuron projection development, protein phosphorylation, regulation of cell population proliferation, regulation of neuron differentiation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, protein kinase activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
integral component of plasma membrane, plasma membrane, membrane, receptor complex...
integral component of plasma membrane, plasma membrane, membrane, receptor complex
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leukocyte receptor tyrosine kinase
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Kaplan plot for LTK in
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*NOTE: the Kaplan plots were collected from OncoLnc