TYK2
Entrez ID: 7297
Full name: tyrosine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Jak
Chromosomal location: 19p13.2
Substructure location: Gatekeeper: 978 A-loop: 1040...1066 G-loop: 596...603, 903...909 αC-helix: 649...663, 938...953
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TYK2
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain....
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
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GO - Biological processes (BP):
cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-27-mediated signaling pathway, intracellular signal transduction, protein phosphorylation, type I interferon signaling pathway...
cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-27-mediated signaling pathway, intracellular signal transduction, protein phosphorylation, type I interferon signaling pathway
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GO - Molecular function (MF):
ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, type 1 angiotensin receptor binding...
ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, type 1 angiotensin receptor binding
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GO - Cellular component (CC):
cytoskeleton, cytosol, extracellular exosome, nucleus, cytoplasm, membrane...
cytoskeleton, cytosol, extracellular exosome, nucleus, cytoplasm, membrane
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tyrosine kinase 2
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Kaplan plot for TYK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc