WEE1
Entrez ID: 7465
Full name: WEE1 G2 checkpoint kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WEE: WEE1
Chromosomal location: 11p15.4
Substructure location: Gatekeeper: 376 A-loop: 462...481 G-loop: 306...313 αC-helix: 338...352
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WEE1
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1...
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
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GO - Biological processes (BP):
cell division, establishment of cell polarity, G2/M transition of mitotic cell cycle, microtubule cytoskeleton organization, mitotic cell cycle checkpoint, negative regulation of G1/S transition of mitotic cell cycle, neuron projection morphogenesis...
cell division, establishment of cell polarity, G2/M transition of mitotic cell cycle, microtubule cytoskeleton organization, mitotic cell cycle checkpoint, negative regulation of G1/S transition of mitotic cell cycle, neuron projection morphogenesis
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GO - Molecular function (MF):
ATP binding, kinase activity, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein tyrosine kinase activity...
ATP binding, kinase activity, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
nucleolus, nucleoplasm, nucleus, cytoplasm...
nucleolus, nucleoplasm, nucleus, cytoplasm
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WEE1 G2 checkpoint kinase
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Gatekeeper
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Kaplan plot for WEE1 in
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*NOTE: the Kaplan plots were collected from OncoLnc