AXL
Entrez ID: 558
Full name: AXL receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Axl
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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AXL
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface ind...
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
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GO - Biological processes (BP):
animal organ regeneration, apoptotic cell clearance, blood vessel remodeling, cell maturation, cell migration, cellular response to extracellular stimulus, cellular response to hydrogen peroxide, cellular response to interferon-alpha, cellular response to lipopolysaccharide, dendritic cell different...
animal organ regeneration, apoptotic cell clearance, blood vessel remodeling, cell maturation, cell migration, cellular response to extracellular stimulus, cellular response to hydrogen peroxide, cellular response to interferon-alpha, cellular response to lipopolysaccharide, dendritic cell differentiation, erythrocyte homeostasis, forebrain cell migration, inflammatory response, innate immune response, multicellular organism development, natural killer cell differentiation, negative regulation of apoptotic process, negative regulation of dendritic cell apoptotic process, negative regulation of interferon-gamma production, negative regulation of lymphocyte activation, negative regulation of neuron apoptotic process, negative regulation of tumor necrosis factor production, nervous system development, neuron migration, neutrophil clearance, ovulation cycle, phagocytosis, platelet activation, positive regulation of cytokine-mediated signaling pathway, positive regulation of kinase activity, positive regulation of natural killer cell differentiation, positive regulation of pinocytosis, positive regulation of protein kinase B signaling, protein kinase B signaling, secretion by cell, signal transduction, spermatogenesis, substrate adhesion-dependent cell spreading, transmembrane receptor protein tyrosine kinase signaling pathway, vagina development, vascular endothelial growth factor receptor signaling pathway, viral entry into host cell
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GO - Molecular function (MF):
ATP binding, myosin heavy chain binding, phosphatidylinositol 3-kinase binding, phosphatidylserine binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity...
ATP binding, myosin heavy chain binding, phosphatidylinositol 3-kinase binding, phosphatidylserine binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, virus receptor activity
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GO - Cellular component (CC):
actin cytoskeleton, extracellular exosome, extracellular space, integral component of plasma membrane, plasma membrane, cell surface, host cell surface, intracellular membrane-bounded organelle, receptor complex...
actin cytoskeleton, extracellular exosome, extracellular space, integral component of plasma membrane, plasma membrane, cell surface, host cell surface, intracellular membrane-bounded organelle, receptor complex
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AXL receptor tyrosine kinase
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Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
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Kaplan plot for AXL in
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*NOTE: the Kaplan plots were collected from OncoLnc