MAPK4
Entrez ID: 5596
Full name: mitogen-activated protein kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: ERK3
Chromosomal location: 18q21.1-q21.2
Substructure location: Gatekeeper: 110 A-loop: 167...193 G-loop: [N/A] αC-helix: [N/A]
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MAPK4
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at...
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
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GO - Biological processes (BP):
cell cycle, cellular response to organic substance, intracellular signal transduction, protein phosphorylation, regulation of gene expression...
cell cycle, cellular response to organic substance, intracellular signal transduction, protein phosphorylation, regulation of gene expression
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GO - Molecular function (MF):
ATP binding, MAP kinase activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, MAP kinase activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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mitogen-activated protein kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc