GRK4
Entrez ID: 2868
Full name: G protein-coupled receptor kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: GRK: GRK
Chromosomal location: 4p16.3
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 193...199 αC-helix: 220...226
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GRK4
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD...
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
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GO - Biological processes (BP):
G protein-coupled receptor internalization, receptor internalization, regulation of G protein-coupled receptor signaling pathway, regulation of rhodopsin mediated signaling pathway, signal transduction...
G protein-coupled receptor internalization, receptor internalization, regulation of G protein-coupled receptor signaling pathway, regulation of rhodopsin mediated signaling pathway, signal transduction
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GO - Molecular function (MF):
ATP binding, G protein-coupled receptor kinase activity, rhodopsin kinase activity...
ATP binding, G protein-coupled receptor kinase activity, rhodopsin kinase activity
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GO - Cellular component (CC):
cytosol, cell cortex, dendrite, neuronal cell body, photoreceptor disc membrane...
cytosol, cell cortex, dendrite, neuronal cell body, photoreceptor disc membrane
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G protein-coupled receptor kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc