TTK
Entrez ID: 7272
Full name: TTK protein kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: TTK
Chromosomal location: 6q14.1
Substructure location: Gatekeeper: 602 A-loop: 663...688 G-loop: [N/A] αC-helix: 557...559
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TTK
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint....
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
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GO - Biological processes (BP):
chromosome segregation, chromosome separation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint, mitotic spindle assembly checkpoint, mitotic spindle organization, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cell population pr...
chromosome segregation, chromosome separation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint, mitotic spindle assembly checkpoint, mitotic spindle organization, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cell population proliferation, positive regulation of pathway-restricted SMAD protein phosphorylation, protein autophosphorylation, protein localization to kinetochore, protein localization to meiotic spindle midzone, spindle organization
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GO - Molecular function (MF):
ATP binding, kinetochore binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, kinetochore binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
spindle, nucleus, cytoplasm, kinetochore, membrane...
spindle, nucleus, cytoplasm, kinetochore, membrane
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TTK protein kinase
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A-loop
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αC-helix
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Kaplan plot for TTK in
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*NOTE: the Kaplan plots were collected from OncoLnc