RYK
Entrez ID: 6259
Full name: receptor like tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Ryk
Chromosomal location: 3q22.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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RYK
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allow...
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
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GO - Biological processes (BP):
axon guidance, axonogenesis, canonical Wnt signaling pathway, cell proliferation in midbrain, chemorepulsion of dopaminergic neuron axon, commissural neuron axon guidance, corpus callosum development, midbrain dopaminergic neuron differentiation, multicellular organism development, negative regulati...
axon guidance, axonogenesis, canonical Wnt signaling pathway, cell proliferation in midbrain, chemorepulsion of dopaminergic neuron axon, commissural neuron axon guidance, corpus callosum development, midbrain dopaminergic neuron differentiation, multicellular organism development, negative regulation of axon extension involved in axon guidance, nervous system development, neurogenesis, neuron differentiation, neuron projection development, non-canonical Wnt signaling pathway, peptidyl-tyrosine phosphorylation, planar cell polarity pathway involved in axon guidance, positive regulation of kinase activity, positive regulation of MAPK cascade, signal transduction, skeletal system morphogenesis, synapse assembly, transmembrane receptor protein tyrosine kinase signaling pathway, Wnt signaling pathway, Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
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GO - Molecular function (MF):
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, frizzled binding, kinase activity, transmembrane signaling receptor activity, Wnt-activated receptor activity, Wnt-protein binding...
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, frizzled binding, kinase activity, transmembrane signaling receptor activity, Wnt-activated receptor activity, Wnt-protein binding
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GO - Cellular component (CC):
nucleus, integral component of plasma membrane, plasma membrane, cytoplasm, integral component of membrane, membrane, receptor complex...
nucleus, integral component of plasma membrane, plasma membrane, cytoplasm, integral component of membrane, membrane, receptor complex
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receptor like tyrosine kinase
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Kaplan plot for RYK in
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*NOTE: the Kaplan plots were collected from OncoLnc