FLT4
Entrez ID: 2324
Full name: fms related receptor tyrosine kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: VEGFR
Chromosomal location: 5q35.3
Substructure location: Gatekeeper: 927 A-loop: 1054...1079 G-loop: [N/A] αC-helix: [N/A]
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FLT4
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endoth...
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
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GO - Biological processes (BP):
blood vessel morphogenesis, cellular response to vascular endothelial growth factor stimulus, lung alveolus development, lymphangiogenesis, lymph vessel development, multicellular organism development, negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation o...
blood vessel morphogenesis, cellular response to vascular endothelial growth factor stimulus, lung alveolus development, lymphangiogenesis, lymph vessel development, multicellular organism development, negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell population proliferation, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of protein kinase C signaling, positive regulation of protein phosphorylation, positive regulation of vascular endothelial growth factor production, protein autophosphorylation, regulation of blood vessel remodeling, respiratory system process, sprouting angiogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway, vasculature development
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GO - Molecular function (MF):
ATP binding, growth factor binding, protein homodimerization activity, protein phosphatase binding, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding, VEGF-C-activated receptor activity...
ATP binding, growth factor binding, protein homodimerization activity, protein phosphatase binding, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding, VEGF-C-activated receptor activity
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GO - Cellular component (CC):
extracellular region, nucleoplasm, integral component of plasma membrane, plasma membrane, cytoplasm, receptor complex...
extracellular region, nucleoplasm, integral component of plasma membrane, plasma membrane, cytoplasm, receptor complex
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fms related receptor tyrosine kinase 4
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Kaplan plot for FLT4 in
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*NOTE: the Kaplan plots were collected from OncoLnc