KDR
Entrez ID: 3791
Full name: kinase insert domain receptor
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: VEGFR
Chromosomal location: 4q12
Substructure location: Gatekeeper: 975 A-loop: 1045...1070 G-loop: 840...846 αC-helix: 876...892
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KDR
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial...
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
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GO - Biological processes (BP):
angiogenesis, calcium-mediated signaling using intracellular calcium source, cell migration, cell migration involved in sprouting angiogenesis, cellular response to hydrogen sulfide, cellular response to vascular endothelial growth factor stimulus, embryonic hemopoiesis, endothelial cell differentia...
angiogenesis, calcium-mediated signaling using intracellular calcium source, cell migration, cell migration involved in sprouting angiogenesis, cellular response to hydrogen sulfide, cellular response to vascular endothelial growth factor stimulus, embryonic hemopoiesis, endothelial cell differentiation, endothelium development, ERK1 and ERK2 cascade, extracellular matrix organization, multicellular organism development, negative regulation of apoptotic process, negative regulation of endothelial cell apoptotic process, negative regulation of gene expression, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell population proliferation, positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of focal adhesion assembly, positive regulation of kinase activity, positive regulation of macroautophagy, positive regulation of MAPK cascade, positive regulation of mitochondrial depolarization, positive regulation of mitochondrial fission, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of positive chemotaxis, positive regulation of protein phosphorylation, positive regulation of vasculogenesis, protein autophosphorylation, protein kinase B signaling, regulation of cell shape, sprouting angiogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, vascular endothelial growth factor receptor signaling pathway, vasculogenesis, viral process
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GO - Molecular function (MF):
ATP binding, cadherin binding, growth factor binding, Hsp90 protein binding, identical protein binding, integrin binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial gr...
ATP binding, cadherin binding, growth factor binding, Hsp90 protein binding, identical protein binding, integrin binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding
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GO - Cellular component (CC):
endoplasmic reticulum, early endosome, endosome, sorting endosome, extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell junction, membrane raft, receptor complex...
endoplasmic reticulum, early endosome, endosome, sorting endosome, extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell junction, membrane raft, receptor complex
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kinase insert domain receptor
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*NOTE: the Kaplan plots were collected from OncoLnc