MAP2K2
Entrez ID: 5605
Full name: mitogen-activated protein kinase kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK1
Chromosomal location: 19p13.3
Substructure location: Gatekeeper: 147 A-loop: 211...232 G-loop: 78...87 αC-helix: 110...119
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MAP2K2
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecu...
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).
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GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, ERK1 and ERK2 cascade, MAPK cascade, negative regulation of gene expression, peptidyl-serine autophosphorylation, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of protein serine...
activation of MAPK activity, activation of protein kinase activity, ERK1 and ERK2 cascade, MAPK cascade, negative regulation of gene expression, peptidyl-serine autophosphorylation, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of protein serine/threonine kinase activity, positive regulation of transcription, DNA-templated, regulation of early endosome to late endosome transport, regulation of Golgi inheritance, regulation of mitotic cell cycle, regulation of stress-activated MAPK cascade, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, MAP-kinase scaffold activity, metal ion binding, PDZ domain binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold pr...
ATP binding, MAP kinase kinase activity, MAP-kinase scaffold activity, metal ion binding, PDZ domain binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold protein binding
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GO - Cellular component (CC):
microtubule, cytosol, endoplasmic reticulum, early endosome, late endosome, extracellular region, Golgi apparatus, mitochondrion, nucleus, peroxisomal membrane, cytoplasmic side of plasma membrane, cell-cell junction, cytoplasm, focal adhesion, perinuclear region of cytoplasm...
microtubule, cytosol, endoplasmic reticulum, early endosome, late endosome, extracellular region, Golgi apparatus, mitochondrion, nucleus, peroxisomal membrane, cytoplasmic side of plasma membrane, cell-cell junction, cytoplasm, focal adhesion, perinuclear region of cytoplasm
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mitogen-activated protein kinase kinase 2
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Kaplan plot for MAP2K2 in
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*NOTE: the Kaplan plots were collected from OncoLnc