FLT3
Entrez ID: 2322
Full name: fms related receptor tyrosine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: PDGFR
Chromosomal location: 13q12.2
Substructure location: Gatekeeper: 691 A-loop: [N/A] G-loop: 616...622 αC-helix: 656...668
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FLT3
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes a...
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
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GO - Biological processes (BP):
animal organ regeneration, B cell differentiation, cellular response to cytokine stimulus, cellular response to glucocorticoid stimulus, common myeloid progenitor cell proliferation, cytokine-mediated signaling pathway, dendritic cell differentiation, hematopoietic progenitor cell differentiation, h...
animal organ regeneration, B cell differentiation, cellular response to cytokine stimulus, cellular response to glucocorticoid stimulus, common myeloid progenitor cell proliferation, cytokine-mediated signaling pathway, dendritic cell differentiation, hematopoietic progenitor cell differentiation, hemopoiesis, leukocyte differentiation, leukocyte homeostasis, lymphocyte differentiation, lymphocyte proliferation, MAPK cascade, multicellular organism development, myeloid progenitor cell differentiation, peptidyl-tyrosine phosphorylation, positive regulation of cell population proliferation, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of MAP kinase activity, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of tyrosine phosphorylation of STAT protein, pro-B cell differentiation, protein autophosphorylation, regulation of apoptotic process, response to organonitrogen compound, transmembrane receptor protein tyrosine kinase signaling pathway, viral process
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GO - Molecular function (MF):
ATP binding, cytokine receptor activity, glucocorticoid receptor binding, growth factor binding, protein-containing complex binding, protein self-association, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity...
ATP binding, cytokine receptor activity, glucocorticoid receptor binding, growth factor binding, protein-containing complex binding, protein self-association, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, nucleus, integral component of plasma membrane, plasma membrane, receptor complex...
cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, nucleus, integral component of plasma membrane, plasma membrane, receptor complex
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fms related receptor tyrosine kinase 3
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Kaplan plot for FLT3 in
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*NOTE: the Kaplan plots were collected from OncoLnc