TGFBR2
Entrez ID: 7048
Full name: transforming growth factor beta receptor 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR2
Chromosomal location: 3p24.1
Substructure location: Gatekeeper: 325 A-loop: 396...423 G-loop: 250...259 αC-helix: 281...283
Please click HERE
for better display.
TGFBR2
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating ...
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
View more >>
GO - Biological processes (BP):
activation of protein kinase activity, aging, animal organ regeneration, apoptotic process, atrioventricular valve morphogenesis, blood vessel development, brain development, branching involved in blood vessel morphogenesis, bronchus morphogenesis, cardiac left ventricle morphogenesis, cellular resp...
activation of protein kinase activity, aging, animal organ regeneration, apoptotic process, atrioventricular valve morphogenesis, blood vessel development, brain development, branching involved in blood vessel morphogenesis, bronchus morphogenesis, cardiac left ventricle morphogenesis, cellular response to growth factor stimulus, common-partner SMAD protein phosphorylation, digestive tract development, embryo implantation, embryonic cranial skeleton morphogenesis, embryonic hemopoiesis, endocardial cushion fusion, gastrulation, growth plate cartilage chondrocyte growth, heart development, heart looping, inferior endocardial cushion morphogenesis, in utero embryonic development, lens development in camera-type eye, lens fiber cell apoptotic process, lung lobe morphogenesis, mammary gland morphogenesis, membranous septum morphogenesis, miRNA transport, myeloid dendritic cell differentiation, negative regulation of cardiac muscle cell proliferation, negative regulation of transforming growth factor beta receptor signaling pathway, Notch signaling pathway, outflow tract morphogenesis, outflow tract septum morphogenesis, pathway-restricted SMAD protein phosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of angiogenesis, positive regulation of B cell tolerance induction, positive regulation of CD4-positive, alpha-beta T cell proliferation, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of mesenchymal cell proliferation, positive regulation of NK T cell differentiation, positive regulation of reactive oxygen species metabolic process, positive regulation of skeletal muscle tissue regeneration, positive regulation of smooth muscle cell proliferation, positive regulation of T cell tolerance induction, positive regulation of tolerance induction to self antigen, protein phosphorylation, receptor-mediated endocytosis, regulation of cell population proliferation, regulation of gene expression, response to cholesterol, response to drug, response to estrogen, response to glucose, response to hypoxia, response to mechanical stimulus, response to nutrient, response to steroid hormone, secondary palate development, smoothened signaling pathway, trachea formation, transforming growth factor beta receptor signaling pathway, tricuspid valve morphogenesis, vasculogenesis, ventricular septum morphogenesis, wound healing
View more >>
GO - Molecular function (MF):
activin-activated receptor activity, activin binding, ATP binding, glycosaminoglycan binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta-activated receptor activity, transforming g...
activin-activated receptor activity, activin binding, ATP binding, glycosaminoglycan binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta-activated receptor activity, transforming growth factor beta binding, transforming growth factor beta receptor activity, type II, transmembrane receptor protein serine/threonine kinase activity, type III transforming growth factor beta receptor binding, type I transforming growth factor beta receptor binding
View more >>
GO - Cellular component (CC):
cytosol, caveola, external side of plasma membrane, integral component of plasma membrane, plasma membrane, integral component of membrane, membrane raft, receptor complex...
cytosol, caveola, external side of plasma membrane, integral component of plasma membrane, plasma membrane, integral component of membrane, membrane raft, receptor complex
View more >>
transforming growth factor beta receptor 2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for TGFBR2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc