CSK
Entrez ID: 1445
Full name: C-terminal Src kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Csk
Chromosomal location: 15q24.1
Substructure location: Gatekeeper: 266 A-loop: 331...351 G-loop: 201...210 αC-helix: 231...235
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CSK
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail ...
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
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GO - Biological processes (BP):
adaptive immune response, adherens junction organization, brain development, cellular response to peptide hormone stimulus, negative regulation of bone resorption, negative regulation of cell population proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of Golgi to plas...
adaptive immune response, adherens junction organization, brain development, cellular response to peptide hormone stimulus, negative regulation of bone resorption, negative regulation of cell population proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of Golgi to plasma membrane protein transport, negative regulation of interleukin-6 production, negative regulation of kinase activity, negative regulation of low-density lipoprotein particle clearance, negative regulation of phagocytosis, oligodendrocyte differentiation, positive regulation of MAP kinase activity, protein autophosphorylation, protein phosphorylation, regulation of Fc receptor mediated stimulatory signaling pathway, T cell costimulation, T cell receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, identical protein binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, proline-rich region binding, protein C-terminus binding, protein kinase A catalytic subunit binding, protein phosphatase binding, protein tyrosine kinase activity...
ATP binding, identical protein binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, proline-rich region binding, protein C-terminus binding, protein kinase A catalytic subunit binding, protein phosphatase binding, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, plasma membrane, cell-cell junction, cytoplasm, membrane raft...
cytosol, extracellular exosome, plasma membrane, cell-cell junction, cytoplasm, membrane raft
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C-terminal Src kinase
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Kaplan plot for CSK in
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*NOTE: the Kaplan plots were collected from OncoLnc