MAP3K8
Entrez ID: 1326
Full name: mitogen-activated protein kinase kinase kinase 8
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE-Unique
Chromosomal location: 10p11.23
Substructure location: Gatekeeper: 207 A-loop: 269...292 G-loop: [N/A] αC-helix: 171...173
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MAP3K8
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression ...
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
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GO - Biological processes (BP):
activation of protein kinase activity, cell cycle, interleukin-1-mediated signaling pathway, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade, T cell costimulati...
activation of protein kinase activity, cell cycle, interleukin-1-mediated signaling pathway, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade, T cell costimulation
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, MAP kinase kinase kinase activity, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, MAP kinase kinase kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, cytoplasm...
cytosol, cytoplasm
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mitogen-activated protein kinase kinase kinase 8
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Kaplan plot for MAP3K8 in
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*NOTE: the Kaplan plots were collected from OncoLnc