PRKCI
Entrez ID: 5584
Full name: protein kinase C iota
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKC: PKCi
Chromosomal location: 3q26.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 260...266 αC-helix: 287...289
Please click HERE
for better display.
PRKCI
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory...
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity).
View more >>
GO - Biological processes (BP):
actin filament organization, bicellular tight junction assembly, cell-cell junction organization, cell migration, cellular response to insulin stimulus, cytoskeleton organization, establishment of apical/basal cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, eye ...
actin filament organization, bicellular tight junction assembly, cell-cell junction organization, cell migration, cellular response to insulin stimulus, cytoskeleton organization, establishment of apical/basal cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, eye photoreceptor cell development, Golgi vesicle budding, intracellular signal transduction, membrane organization, negative regulation of apoptotic process, negative regulation of glial cell apoptotic process, negative regulation of neuron apoptotic process, peptidyl-serine phosphorylation, positive regulation of endothelial cell apoptotic process, positive regulation of glial cell proliferation, positive regulation of glucose import, positive regulation of neuron projection development, positive regulation of NF-kappaB transcription factor activity, positive regulation of Notch signaling pathway, positive regulation of protein localization to plasma membrane, protein phosphorylation, protein targeting to membrane, regulation of postsynaptic membrane neurotransmitter receptor levels, response to interleukin-1, secretion, vesicle-mediated transport
View more >>
GO - Molecular function (MF):
ATP binding, calcium-dependent protein kinase C activity, metal ion binding, phospholipid binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity...
ATP binding, calcium-dependent protein kinase C activity, metal ion binding, phospholipid binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
microtubule cytoskeleton, cytosol, endosome, extracellular exosome, intercellular bridge, Golgi membrane, nucleoplasm, nucleus, apical plasma membrane, plasma membrane, bicellular tight junction, cell leading edge, glutamatergic synapse, Schaffer collateral - CA1 synapse, Schmidt-Lanterman incisure...
microtubule cytoskeleton, cytosol, endosome, extracellular exosome, intercellular bridge, Golgi membrane, nucleoplasm, nucleus, apical plasma membrane, plasma membrane, bicellular tight junction, cell leading edge, glutamatergic synapse, Schaffer collateral - CA1 synapse, Schmidt-Lanterman incisure
View more >>
protein kinase C iota
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for PRKCI in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc