PIK3CA
Entrez ID: 5290
Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PI3/PI4
Chromosomal location: 3q26.32
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
PIK3CA
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contain...
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
View more >>
GO - Biological processes (BP):
adipose tissue development, angiogenesis, anoikis, axon guidance, cardiac muscle contraction, cell migration, cellular response to glucose stimulus, cytokine-mediated signaling pathway, endothelial cell migration, energy homeostasis, epidermal growth factor receptor signaling pathway, ERBB2 signalin...
adipose tissue development, angiogenesis, anoikis, axon guidance, cardiac muscle contraction, cell migration, cellular response to glucose stimulus, cytokine-mediated signaling pathway, endothelial cell migration, energy homeostasis, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, glucose metabolic process, G protein-coupled receptor signaling pathway, hypomethylation of CpG island, insulin receptor signaling pathway via phosphatidylinositol 3-kinase, leukocyte migration, liver development, negative regulation of anoikis, negative regulation of fibroblast apoptotic process, negative regulation of macroautophagy, negative regulation of neuron apoptotic process, phosphatidylinositol 3-kinase signaling, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-mediated signaling, phosphatidylinositol phosphorylation, phosphorylation, platelet activation, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein kinase B signaling, positive regulation of TOR signaling, protein kinase B signaling, regulation of cellular respiration, regulation of gene expression, regulation of genetic imprinting, regulation of multicellular organism growth, T cell costimulation, T cell receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway, vasculature development
View more >>
GO - Molecular function (MF):
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, insulin receptor substrate binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-k...
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, insulin receptor substrate binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphatidylinositol kinase activity, protein kinase activator activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytosol, plasma membrane, cell, cytoplasm, lamellipodium, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA...
cytosol, plasma membrane, cell, cytoplasm, lamellipodium, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA
View more >>
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for PIK3CA in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc