PIK3CB
Entrez ID: 5291
Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PI3/PI4
Chromosomal location: 3q22.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PIK3CB
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contain...
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
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GO - Biological processes (BP):
activation of MAPK activity, autophagy, axon guidance, cell migration, chemotaxis, cytokine-mediated signaling pathway, endocytosis, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, leukocyte migration,...
activation of MAPK activity, autophagy, axon guidance, cell migration, chemotaxis, cytokine-mediated signaling pathway, endocytosis, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, G protein-coupled receptor signaling pathway, leukocyte migration, phosphatidylinositol 3-kinase signaling, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-mediated signaling, phosphatidylinositol phosphorylation, phosphorylation, platelet activation, platelet aggregation, positive regulation of autophagy, positive regulation of gene expression, positive regulation of neutrophil apoptotic process, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein kinase B signaling, regulation of cell-matrix adhesion, regulation of clathrin-dependent endocytosis, signal transduction, T cell receptor signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, vascular endothelial growth factor receptor signaling pathway
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GO - Molecular function (MF):
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphatidylinositol...
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphatidylinositol kinase activity
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GO - Cellular component (CC):
cytosol, nucleolus, nucleoplasm, plasma membrane, cytoplasm, intracellular membrane-bounded organelle, membrane, midbody, phosphatidylinositol 3-kinase complex...
cytosol, nucleolus, nucleoplasm, plasma membrane, cytoplasm, intracellular membrane-bounded organelle, membrane, midbody, phosphatidylinositol 3-kinase complex
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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
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Gatekeeper
A-loop
G-loop
αC-helix
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αC-helix
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Kaplan plot for PIK3CB in
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*NOTE: the Kaplan plots were collected from OncoLnc