MATK
Entrez ID: 4145
Full name: megakaryocyte-associated tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Csk
Chromosomal location: 19p13.3
Substructure location: Gatekeeper: 304 A-loop: 369...389 G-loop: [N/A] αC-helix: [N/A]
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MATK
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role ...
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
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GO - Biological processes (BP):
ERBB2 signaling pathway, positive regulation of cell population proliferation, protein phosphorylation...
ERBB2 signaling pathway, positive regulation of cell population proliferation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, membrane...
cytosol, membrane
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megakaryocyte-associated tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc