TEC
Entrez ID: 7006
Full name: tec protein tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Tec
Chromosomal location: 4p12-p11
Substructure location: Gatekeeper: 442 A-loop: 506...530 G-loop: [N/A] αC-helix: [N/A]
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TEC
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the developme...
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
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GO - Biological processes (BP):
adaptive immune response, B cell receptor signaling pathway, cytokine-mediated signaling pathway, Fc-epsilon receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulati...
adaptive immune response, B cell receptor signaling pathway, cytokine-mediated signaling pathway, Fc-epsilon receptor signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, protein phosphorylation, regulation of platelet activation, T cell receptor signaling pathway, tissue regeneration
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GO - Molecular function (MF):
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, phospholipid binding...
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, phospholipid binding
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GO - Cellular component (CC):
cytoskeleton, cytosol, plasma membrane...
cytoskeleton, cytosol, plasma membrane
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tec protein tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc