TXK
Entrez ID: 7294
Full name: TXK tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Tec
Chromosomal location: 4p12
Substructure location: Gatekeeper: 343 A-loop: 407...431 G-loop: [N/A] αC-helix: [N/A]
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TXK
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series...
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
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GO - Biological processes (BP):
activation of phospholipase C activity, adaptive immune response, cytokine production, peptidyl-tyrosine autophosphorylation, positive regulation of interferon-gamma-mediated signaling pathway, positive regulation of interferon-gamma production, positive regulation of transcription by RNA polymerase...
activation of phospholipase C activity, adaptive immune response, cytokine production, peptidyl-tyrosine autophosphorylation, positive regulation of interferon-gamma-mediated signaling pathway, positive regulation of interferon-gamma production, positive regulation of transcription by RNA polymerase II, protein autophosphorylation, protein phosphorylation, regulation of transcription by RNA polymerase II, T cell receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, DNA-binding transcription activator activity, RNA polymerase II-specific, non-membrane spanning protein tyrosine kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II regulatory region DNA binding...
ATP binding, DNA-binding transcription activator activity, RNA polymerase II-specific, non-membrane spanning protein tyrosine kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II regulatory region DNA binding
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GO - Cellular component (CC):
nucleus, plasma membrane, cytoplasm...
nucleus, plasma membrane, cytoplasm
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TXK tyrosine kinase
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Kaplan plot for TXK in
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*NOTE: the Kaplan plots were collected from OncoLnc