FRK
Entrez ID: 2444
Full name: fyn related Src family tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Src: Frk
Chromosomal location: 6q22.1
Substructure location: Gatekeeper: 306 A-loop: 371...380, 384...398 G-loop: [N/A] αC-helix: [N/A]
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FRK
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor s...
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
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GO - Biological processes (BP):
cell differentiation, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, neutrophil degranulation, peptidyl-tyrosine autophosphorylation, protein phosphorylation, regulation of cell population proliferation, transmembrane receptor protein...
cell differentiation, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, neutrophil degranulation, peptidyl-tyrosine autophosphorylation, protein phosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
cytosol, extracellular exosome, extracellular region, azurophil granule lumen, nucleoplasm, nucleus, extrinsic component of cytoplasmic side of plasma membrane, intracellular, specific granule lumen...
cytosol, extracellular exosome, extracellular region, azurophil granule lumen, nucleoplasm, nucleus, extrinsic component of cytoplasmic side of plasma membrane, intracellular, specific granule lumen
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fyn related Src family tyrosine kinase
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Kaplan plot for FRK in
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*NOTE: the Kaplan plots were collected from OncoLnc