GRK6
Entrez ID: 2870
Full name: G protein-coupled receptor kinase 6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: GRK: GRK
Chromosomal location: 5q35.3
Substructure location: Gatekeeper: 263 A-loop: 328...350 G-loop: 193...200 αC-helix: 219...224
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GRK6
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopa...
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
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GO - Biological processes (BP):
G protein-coupled receptor signaling pathway, regulation of G protein-coupled receptor signaling pathway, Wnt signaling pathway...
G protein-coupled receptor signaling pathway, regulation of G protein-coupled receptor signaling pathway, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, beta-adrenergic receptor kinase activity, G protein-coupled receptor kinase activity...
ATP binding, beta-adrenergic receptor kinase activity, G protein-coupled receptor kinase activity
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GO - Cellular component (CC):
plasma membrane, membrane...
plasma membrane, membrane
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G protein-coupled receptor kinase 6
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Kaplan plot for GRK6 in
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*NOTE: the Kaplan plots were collected from OncoLnc