ZAP70
Entrez ID: 7535
Full name: zeta chain of T cell receptor associated protein kinase 70
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Syk
Chromosomal location: 2q11.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 343...352 αC-helix: 377...392
Please click HERE
for better display.
ZAP70
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting c...
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).
View more >>
GO - Biological processes (BP):
adaptive immune response, B cell activation, beta selection, immune response, intracellular signal transduction, negative thymic T cell selection, peptidyl-tyrosine phosphorylation, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, posi...
adaptive immune response, B cell activation, beta selection, immune response, intracellular signal transduction, negative thymic T cell selection, peptidyl-tyrosine phosphorylation, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, positive regulation of calcium-mediated signaling, positive regulation of T cell differentiation, positive thymic T cell selection, protein autophosphorylation, protein phosphorylation, T cell activation, T cell aggregation, T cell differentiation, T cell migration, T cell receptor signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity...
ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity
View more >>
GO - Cellular component (CC):
cytosol, immunological synapse, plasma membrane, T cell receptor complex, cell-cell junction, cytoplasm...
cytosol, immunological synapse, plasma membrane, T cell receptor complex, cell-cell junction, cytoplasm
View more >>
zeta chain of T cell receptor associated protein kinase 70
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for ZAP70 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc