MAPK9
Entrez ID: 5601
Full name: mitogen-activated protein kinase 9
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: MAPK: JNK
Chromosomal location: 5q35.3
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 31...40 αC-helix: 64...79
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MAPK9
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal ki...
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).
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GO - Biological processes (BP):
cellular response to cadmium ion, cellular response to reactive oxygen species, Fc-epsilon receptor signaling pathway, intracellular signal transduction, JNK cascade, peptidyl-serine phosphorylation, positive regulation of apoptotic signaling pathway, positive regulation of gene expression, positive...
cellular response to cadmium ion, cellular response to reactive oxygen species, Fc-epsilon receptor signaling pathway, intracellular signal transduction, JNK cascade, peptidyl-serine phosphorylation, positive regulation of apoptotic signaling pathway, positive regulation of gene expression, positive regulation of macrophage derived foam cell differentiation, positive regulation of podosome assembly, positive regulation of protein ubiquitination, positive regulation of transcription factor catabolic process, protein localization to tricellular tight junction, protein phosphorylation, regulation of circadian rhythm, regulation of DNA-binding transcription factor activity, regulation of gene expression, rhythmic process
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GO - Molecular function (MF):
ATP binding, JUN kinase activity, MAP kinase activity, protein serine/threonine/tyrosine kinase activity, transcription factor binding...
ATP binding, JUN kinase activity, MAP kinase activity, protein serine/threonine/tyrosine kinase activity, transcription factor binding
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GO - Cellular component (CC):
cytosol, mitochondrion, nucleoplasm, nucleus, cytoplasm...
cytosol, mitochondrion, nucleoplasm, nucleus, cytoplasm
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mitogen-activated protein kinase 9
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*NOTE: the Kaplan plots were collected from OncoLnc