MAP2K3
Entrez ID: 5606
Full name: mitogen-activated protein kinase kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK3
Chromosomal location: 17p11.2
Substructure location: Gatekeeper: 140 A-loop: 207...222, 224...229 G-loop: [N/A] αC-helix: [N/A]
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MAP2K3
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the a...
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
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GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, cardiac muscle contraction, cellular response to vascular endothelial growth factor stimulus, inflammatory response, p38MAPK cascade, positive regulation of blood vessel endothelial cell migration, positive regulation of protein kin...
activation of MAPK activity, activation of protein kinase activity, cardiac muscle contraction, cellular response to vascular endothelial growth factor stimulus, inflammatory response, p38MAPK cascade, positive regulation of blood vessel endothelial cell migration, positive regulation of protein kinase activity, positive regulation of transcription, DNA-templated, regulation of cytokine biosynthetic process, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, MAP kinase kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, cytoplasm, membrane...
cytosol, nucleoplasm, cytoplasm, membrane
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mitogen-activated protein kinase kinase 3
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Kaplan plot for MAP2K3 in
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*NOTE: the Kaplan plots were collected from OncoLnc