CSNK1A1
Entrez ID: 1452
Full name: casein kinase 1 alpha 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: CK1: CK1-A
Chromosomal location: 5q32
Substructure location: Gatekeeper: 90 A-loop: 156...186 G-loop: 22...29 αC-helix: 57...67
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CSNK1A1
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregat...
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
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GO - Biological processes (BP):
beta-catenin destruction complex assembly, beta-catenin destruction complex disassembly, cell cycle, cell division, cell morphogenesis, cell surface receptor signaling pathway, Golgi organization, intermediate filament cytoskeleton organization, negative regulation of canonical Wnt signaling pathway...
beta-catenin destruction complex assembly, beta-catenin destruction complex disassembly, cell cycle, cell division, cell morphogenesis, cell surface receptor signaling pathway, Golgi organization, intermediate filament cytoskeleton organization, negative regulation of canonical Wnt signaling pathway, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein phosphorylation, regulation of GTP binding, signal transduction, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, kinase activity, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, kinase activity, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, ciliary basal body, cytosol, nuclear speck, nucleus, beta-catenin destruction complex, cilium, condensed chromosome kinetochore, cytoplasm, membrane, ribonucleoprotein complex...
centrosome, ciliary basal body, cytosol, nuclear speck, nucleus, beta-catenin destruction complex, cilium, condensed chromosome kinetochore, cytoplasm, membrane, ribonucleoprotein complex
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casein kinase 1 alpha 1
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Kaplan plot for CSNK1A1 in
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*NOTE: the Kaplan plots were collected from OncoLnc