CSNK1D
Entrez ID: 1453
Full name: casein kinase 1 delta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: CK1: CK1-D
Chromosomal location: 17q25.3
Substructure location: Gatekeeper: 82 A-loop: 148...158, 160...178 G-loop: 14...23 αC-helix: 49...59
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CSNK1D
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic pro...
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
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GO - Biological processes (BP):
ciliary basal body-plasma membrane docking, circadian regulation of gene expression, COPII vesicle coating, G2/M transition of mitotic cell cycle, Golgi organization, microtubule nucleation, non-motile cilium assembly, peptidyl-serine phosphorylation, positive regulation of canonical Wnt signaling p...
ciliary basal body-plasma membrane docking, circadian regulation of gene expression, COPII vesicle coating, G2/M transition of mitotic cell cycle, Golgi organization, microtubule nucleation, non-motile cilium assembly, peptidyl-serine phosphorylation, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation, protein localization to centrosome, protein localization to cilium, protein localization to Golgi apparatus, protein phosphorylation, regulation of circadian rhythm, regulation of G2/M transition of mitotic cell cycle, spindle assembly, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, cadherin binding, protein kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity...
ATP binding, cadherin binding, protein kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity
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GO - Cellular component (CC):
centrosome, spindle, spindle microtubule, cytosol, Golgi apparatus, Golgi membrane, nucleoplasm, nucleus, plasma membrane, cytoplasm, endoplasmic reticulum-Golgi intermediate compartment membrane, perinuclear region of cytoplasm...
centrosome, spindle, spindle microtubule, cytosol, Golgi apparatus, Golgi membrane, nucleoplasm, nucleus, plasma membrane, cytoplasm, endoplasmic reticulum-Golgi intermediate compartment membrane, perinuclear region of cytoplasm
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casein kinase 1 delta
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Kaplan plot for CSNK1D in
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*NOTE: the Kaplan plots were collected from OncoLnc