PIK3CG
Entrez ID: 5294
Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PI3/PI4
Chromosomal location: 7q22.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PIK3CG
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling ca...
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
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GO - Biological processes (BP):
adaptive immune response, angiogenesis, cell migration, cellular response to cAMP, cytokine production, dendritic cell chemotaxis, endocytosis, G protein-coupled receptor signaling pathway, hepatocyte apoptotic process, inflammatory response, innate immune response, mast cell degranulation, natural ...
adaptive immune response, angiogenesis, cell migration, cellular response to cAMP, cytokine production, dendritic cell chemotaxis, endocytosis, G protein-coupled receptor signaling pathway, hepatocyte apoptotic process, inflammatory response, innate immune response, mast cell degranulation, natural killer cell chemotaxis, negative regulation of cardiac muscle contraction, negative regulation of fibroblast apoptotic process, negative regulation of triglyceride catabolic process, neutrophil chemotaxis, neutrophil extravasation, phosphatidylinositol 3-kinase signaling, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol biosynthetic process, phosphatidylinositol-mediated signaling, phosphatidylinositol phosphorylation, phosphorylation, platelet activation, platelet aggregation, positive regulation of acute inflammatory response, positive regulation of cytosolic calcium ion concentration, positive regulation of MAP kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein kinase B signaling, regulation of calcium ion transmembrane transport, regulation of cell adhesion mediated by integrin, respiratory burst involved in defense response, secretory granule localization, T cell activation, T cell chemotaxis, T cell proliferation
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GO - Molecular function (MF):
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, ephrin receptor binding, identical protein binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-...
1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, ephrin receptor binding, identical protein binding, kinase activity, phosphatidylinositol-3,4-bisphosphate 5-kinase activity, phosphatidylinositol 3-kinase activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, phosphatidylinositol kinase activity, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, mast cell granule, plasma membrane, cell, cytoplasm, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IB...
cytosol, mast cell granule, plasma membrane, cell, cytoplasm, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IB
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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
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Kaplan plot for PIK3CG in
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*NOTE: the Kaplan plots were collected from OncoLnc