MAPKAPK2
Entrez ID: 9261
Full name: MAPK activated protein kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: MAPKAPK: MK2
Chromosomal location: 1q32.1
Substructure location: Gatekeeper: 138 A-loop: 206...228 G-loop: 71...78 αC-helix: 99...111
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MAPKAPK2
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP...
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X2-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
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GO - Biological processes (BP):
3'-UTR-mediated mRNA stabilization, activation of MAPK activity, cellular response to DNA damage stimulus, cellular response to vascular endothelial growth factor stimulus, inflammatory response, inner ear development, intracellular signal transduction, leukotriene metabolic process, macropinocytosi...
3'-UTR-mediated mRNA stabilization, activation of MAPK activity, cellular response to DNA damage stimulus, cellular response to vascular endothelial growth factor stimulus, inflammatory response, inner ear development, intracellular signal transduction, leukotriene metabolic process, macropinocytosis, MAPK cascade, p38MAPK cascade, peptidyl-serine phosphorylation, positive regulation of tumor necrosis factor biosynthetic process, protein autophosphorylation, protein phosphorylation, regulation of cellular response to heat, regulation of interleukin-6 production, regulation of mRNA stability, regulation of tumor necrosis factor production, response to cytokine, response to lipopolysaccharide, toll-like receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, mitogen-activated protein kinase binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, mitogen-activated protein kinase binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, cytosol, extracellular exosome, nucleoplasm, nucleus, cytoplasm...
centrosome, cytosol, extracellular exosome, nucleoplasm, nucleus, cytoplasm
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MAPK activated protein kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc