CDK8
Entrez ID: 1024
Full name: cyclin dependent kinase 8
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK8
Chromosomal location: 13q12.13
Substructure location: Gatekeeper: 97 A-loop: 172...198 G-loop: [N/A] αC-helix: 61...72
Please click HERE
for better display.
CDK8
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is r...
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
View more >>
GO - Biological processes (BP):
positive regulation of transcription by RNA polymerase II, protein phosphorylation, transcription initiation from RNA polymerase II promoter...
positive regulation of transcription by RNA polymerase II, protein phosphorylation, transcription initiation from RNA polymerase II promoter
View more >>
GO - Molecular function (MF):
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity...
ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity
View more >>
GO - Cellular component (CC):
mediator complex, nucleolus, nucleoplasm, nucleus, protein-containing complex...
mediator complex, nucleolus, nucleoplasm, nucleus, protein-containing complex
View more >>
cyclin dependent kinase 8
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for CDK8 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc