CSNK1E
Entrez ID: 1454
Full name: casein kinase 1 epsilon
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: CK1: CK1-D
Chromosomal location: 22q13.1
Substructure location: Gatekeeper: 82 A-loop: 148...158, 160...178 G-loop: [N/A] αC-helix: 51...56
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CSNK1E
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, deter...
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
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GO - Biological processes (BP):
canonical Wnt signaling pathway, ciliary basal body-plasma membrane docking, circadian regulation of gene expression, DNA repair, G2/M transition of mitotic cell cycle, negative regulation of protein binding, peptidyl-serine phosphorylation, positive regulation of non-canonical Wnt signaling pathway...
canonical Wnt signaling pathway, ciliary basal body-plasma membrane docking, circadian regulation of gene expression, DNA repair, G2/M transition of mitotic cell cycle, negative regulation of protein binding, peptidyl-serine phosphorylation, positive regulation of non-canonical Wnt signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation, protein phosphorylation, regulation of cellular protein localization, regulation of circadian rhythm, regulation of G2/M transition of mitotic cell cycle, signal transduction, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity, RNA binding...
ATP binding, protein kinase activity, protein serine/threonine kinase activity, RNA binding
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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casein kinase 1 epsilon
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Kaplan plot for CSNK1E in
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*NOTE: the Kaplan plots were collected from OncoLnc