CLK1
Entrez ID: 1195
Full name: CDC like kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CLK
Chromosomal location: 2q33.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 168...175 αC-helix: 197...216
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CLK1
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylate...
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
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GO - Biological processes (BP):
peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, protein autophosphorylation, regulation of RNA splicing...
peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, protein autophosphorylation, regulation of RNA splicing
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, cytoplasm...
nucleus, cytoplasm
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CDC like kinase 1
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Kaplan plot for CLK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc