CLK2
Entrez ID: 1196
Full name: CDC like kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CLK
Chromosomal location: 1q22
Substructure location: Gatekeeper: 243 A-loop: 326...346 G-loop: 170...177 αC-helix: 199...218
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CLK2
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause red...
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210).
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GO - Biological processes (BP):
negative regulation of gluconeogenesis, protein autophosphorylation, protein phosphorylation, regulation of RNA splicing, response to ionizing radiation, response to retinoic acid...
negative regulation of gluconeogenesis, protein autophosphorylation, protein phosphorylation, regulation of RNA splicing, response to ionizing radiation, response to retinoic acid
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GO - Molecular function (MF):
ATP binding, identical protein binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, identical protein binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
nuclear body, nuclear speck, nucleoplasm, nucleus...
nuclear body, nuclear speck, nucleoplasm, nucleus
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CDC like kinase 2
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Kaplan plot for CLK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc