CLK3
Entrez ID: 1198
Full name: CDC like kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CLK
Chromosomal location: 15q24.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 311...318 αC-helix: 340...359
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CLK3
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause red...
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
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GO - Biological processes (BP):
protein autophosphorylation, protein phosphorylation, regulation of RNA splicing...
protein autophosphorylation, protein phosphorylation, regulation of RNA splicing
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GO - Molecular function (MF):
ATP binding, identical protein binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, RNA binding...
ATP binding, identical protein binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, RNA binding
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GO - Cellular component (CC):
intermediate filament cytoskeleton, nuclear speck, nucleoplasm, nucleus, acrosomal vesicle, membrane...
intermediate filament cytoskeleton, nuclear speck, nucleoplasm, nucleus, acrosomal vesicle, membrane
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CDC like kinase 3
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Minimum 10 samples
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Kaplan plot for CLK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc