CDK7
Entrez ID: 1022
Full name: cyclin dependent kinase 7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK7
Chromosomal location: 5q13.2
Substructure location: Gatekeeper: 91 A-loop: 154...165, 167...177 G-loop: 19...26 αC-helix: 58...68
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CDK7
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 sub...
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
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GO - Biological processes (BP):
7-methylguanosine mRNA capping, androgen receptor signaling pathway, cell cycle arrest, cell division, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, nucleotide-excision repair, preincision complex assembly, positive regulation of transcription, DNA-templated, positive...
7-methylguanosine mRNA capping, androgen receptor signaling pathway, cell cycle arrest, cell division, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, nucleotide-excision repair, preincision complex assembly, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, protein phosphorylation, protein stabilization, regulation of cyclin-dependent protein serine/threonine kinase activity, snRNA transcription by RNA polymerase II, termination of RNA polymerase I transcription, transcription by RNA polymerase II, transcription-coupled nucleotide-excision repair, transcription elongation from RNA polymerase II promoter, transcription elongation from RNA polymerase I promoter, transcription initiation from RNA polymerase II promoter, transcription initiation from RNA polymerase I promoter
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GO - Molecular function (MF):
androgen receptor binding, ATP binding, cyclin-dependent protein serine/threonine kinase activity, DNA-dependent ATPase activity, kinase activity, protein C-terminus binding, protein kinase activity, protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity,...
androgen receptor binding, ATP binding, cyclin-dependent protein serine/threonine kinase activity, DNA-dependent ATPase activity, kinase activity, protein C-terminus binding, protein kinase activity, protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription coactivator activity
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GO - Cellular component (CC):
cyclin-dependent protein kinase activating kinase holoenzyme complex, nucleoplasm, nucleus, transcription factor TFIIH holo complex, transcription factor TFIIK complex, cytoplasm, perinuclear region of cytoplasm...
cyclin-dependent protein kinase activating kinase holoenzyme complex, nucleoplasm, nucleus, transcription factor TFIIH holo complex, transcription factor TFIIK complex, cytoplasm, perinuclear region of cytoplasm
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cyclin dependent kinase 7
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*NOTE: the Kaplan plots were collected from OncoLnc