CDK9
Entrez ID: 1025
Full name: cyclin dependent kinase 9
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK9
Chromosomal location: 9q34.11
Substructure location: Gatekeeper: 103 A-loop: 166...180, 183...193 G-loop: [N/A] αC-helix: 61...72
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CDK9
Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Member of the cyclin-dependent kinase pair (CDK9/cyc...
Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF (PubMed:9857195, PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:20081228, PubMed:20980437, PubMed:21127351). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:9857195, PubMed:10912001, PubMed:11112772). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670).
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GO - Biological processes (BP):
cell population proliferation, cellular response to cytokine stimulus, DNA repair, negative regulation of cell cycle arrest, negative regulation of mRNA polyadenylation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of cardiac muscle hypertrophy, positive regulation of ...
cell population proliferation, cellular response to cytokine stimulus, DNA repair, negative regulation of cell cycle arrest, negative regulation of mRNA polyadenylation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of cardiac muscle hypertrophy, positive regulation of histone H2B ubiquitination, positive regulation of histone phosphorylation, positive regulation of mRNA 3'-UTR binding, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation from RNA polymerase II promoter, positive regulation of viral transcription, protein phosphorylation, regulation of DNA repair, regulation of histone modification, regulation of muscle cell differentiation, replication fork processing, response to drug, snRNA transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter
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GO - Molecular function (MF):
7SK snRNA binding, ATP binding, chromatin binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, DNA binding, kinase activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, RNA polymerase II cis-regulatory region sequence-spec...
7SK snRNA binding, ATP binding, chromatin binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, DNA binding, kinase activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription coactivator binding, transcription factor binding, transcription regulatory region DNA binding
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GO - Cellular component (CC):
cyclin/CDK positive transcription elongation factor complex, nuclear chromatin, nucleoplasm, nucleus, PML body, transcription elongation factor complex, chromosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasmic ribonucleoprotein granule, membrane...
cyclin/CDK positive transcription elongation factor complex, nuclear chromatin, nucleoplasm, nucleus, PML body, transcription elongation factor complex, chromosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasmic ribonucleoprotein granule, membrane
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cyclin dependent kinase 9
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*NOTE: the Kaplan plots were collected from OncoLnc