BMX
Entrez ID: 660
Full name: BMX non-receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Tec
Chromosomal location: Xp22.2
Substructure location: Gatekeeper: 489 A-loop: 553...577 G-loop: 424...431 αC-helix: 454...466
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BMX
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth fact...
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
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GO - Biological processes (BP):
apoptotic process, cell adhesion, intracellular signal transduction, mesoderm development, phosphatidylinositol biosynthetic process, protein autophosphorylation, protein phosphorylation, signal transduction...
apoptotic process, cell adhesion, intracellular signal transduction, mesoderm development, phosphatidylinositol biosynthetic process, protein autophosphorylation, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity...
ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, plasma membrane, ruffle membrane...
cytosol, nucleoplasm, plasma membrane, ruffle membrane
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BMX non-receptor tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc