PRKX
Entrez ID: 5613
Full name: protein kinase X-linked
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKA
Chromosomal location: Xp22.33
Substructure location: Gatekeeper: 126 A-loop: 189...209 G-loop: [N/A] αC-helix: [N/A]
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PRKX
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation thr...
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
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GO - Biological processes (BP):
angiogenesis, cell adhesion, cell-substrate adhesion, endothelial cell migration, endothelial cell proliferation, epithelial tube morphogenesis, kidney morphogenesis, myeloid cell differentiation, peptidyl-serine phosphorylation, protein autophosphorylation, regulation of cell adhesion, regulation o...
angiogenesis, cell adhesion, cell-substrate adhesion, endothelial cell migration, endothelial cell proliferation, epithelial tube morphogenesis, kidney morphogenesis, myeloid cell differentiation, peptidyl-serine phosphorylation, protein autophosphorylation, regulation of cell adhesion, regulation of cell migration, regulation of epithelial cell differentiation involved in kidney development, signal transduction
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GO - Molecular function (MF):
ATP binding, cAMP-dependent protein kinase activity...
ATP binding, cAMP-dependent protein kinase activity
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GO - Cellular component (CC):
nucleoplasm, nucleus, cAMP-dependent protein kinase complex, cytoplasm...
nucleoplasm, nucleus, cAMP-dependent protein kinase complex, cytoplasm
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protein kinase X-linked
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*NOTE: the Kaplan plots were collected from OncoLnc