NEK2
Entrez ID: 4751
Full name: NIMA related kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK2
Chromosomal location: 1q32.3
Substructure location: Gatekeeper: 86 A-loop: 158...170, 173...181 G-loop: 14...20 αC-helix: 41...43
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NEK2
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphoryl...
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856).
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GO - Biological processes (BP):
blastocyst development, cell division, centrosome separation, chromosome segregation, ciliary basal body-plasma membrane docking, G2/M transition of mitotic cell cycle, meiotic cell cycle, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly, negative regulation of cent...
blastocyst development, cell division, centrosome separation, chromosome segregation, ciliary basal body-plasma membrane docking, G2/M transition of mitotic cell cycle, meiotic cell cycle, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly, negative regulation of centriole-centriole cohesion, negative regulation of DNA binding, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, protein autophosphorylation, protein phosphorylation, regulation of attachment of spindle microtubules to kinetochore, regulation of G2/M transition of mitotic cell cycle, regulation of mitotic centrosome separation, regulation of mitotic nuclear division, spindle assembly
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, protein phosphatase binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein kinase activity, protein phosphatase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, microtubule, spindle pole, cytosol, condensed nuclear chromosome, nucleolus, nucleoplasm, nucleus, condensed chromosome kinetochore, cytoplasm, kinetochore, midbody, protein-containing complex...
centrosome, microtubule, spindle pole, cytosol, condensed nuclear chromosome, nucleolus, nucleoplasm, nucleus, condensed chromosome kinetochore, cytoplasm, kinetochore, midbody, protein-containing complex
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NIMA related kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for NEK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc