NEK3
Entrez ID: 4752
Full name: NIMA related kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK1
Chromosomal location: 13q14.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NEK3
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast ca...
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
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GO - Biological processes (BP):
cell division, establishment of cell polarity, mitotic cell cycle, neuron projection morphogenesis, protein phosphorylation, regulation of tubulin deacetylation...
cell division, establishment of cell polarity, mitotic cell cycle, neuron projection morphogenesis, protein phosphorylation, regulation of tubulin deacetylation
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, axon, cytoplasm...
nucleus, axon, cytoplasm
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NIMA related kinase 3
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
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Kaplan plot for NEK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc