NEK4
Entrez ID: 6787
Full name: NIMA related kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK4
Chromosomal location: 3p21.1
Substructure location: Gatekeeper: 83 A-loop: 148...171 G-loop: [N/A] αC-helix: [N/A]
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NEK4
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage....
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
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GO - Biological processes (BP):
activation of protein kinase activity, cell division, cellular response to DNA damage stimulus, mitotic cell cycle, positive regulation of transcription, DNA-templated, protein phosphorylation, regulation of cellular senescence, regulation of mitotic cell cycle, regulation of replicative cell aging,...
activation of protein kinase activity, cell division, cellular response to DNA damage stimulus, mitotic cell cycle, positive regulation of transcription, DNA-templated, protein phosphorylation, regulation of cellular senescence, regulation of mitotic cell cycle, regulation of replicative cell aging, regulation of response to DNA damage stimulus, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, manganese ion binding, protein serine/threonine kinase activity...
ATP binding, manganese ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
ciliary basal body, ciliary rootlet, cytosol, ciliary plasm, ciliary transition zone, cytoplasm...
ciliary basal body, ciliary rootlet, cytosol, ciliary plasm, ciliary transition zone, cytoplasm
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NIMA related kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc