JAK3
Entrez ID: 3718
Full name: Janus kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Jak
Chromosomal location: 19p13.11
Substructure location: Gatekeeper: 902 A-loop: 966...992 G-loop: 828...834 αC-helix: 862...877
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JAK3
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in si...
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
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GO - Biological processes (BP):
adaptive immune response, B cell differentiation, cytokine-mediated signaling pathway, enzyme linked receptor protein signaling pathway, erythrocyte differentiation, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, interleukin-15-mediated signaling pathway, interleukin...
adaptive immune response, B cell differentiation, cytokine-mediated signaling pathway, enzyme linked receptor protein signaling pathway, erythrocyte differentiation, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, interleukin-15-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-4-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, intracellular signal transduction, MAPK cascade, negative regulation of dendritic cell cytokine production, negative regulation of FasL biosynthetic process, negative regulation of interleukin-10 production, negative regulation of interleukin-12 production, negative regulation of T cell activation, negative regulation of T-helper 1 cell differentiation, negative regulation of thymocyte apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of T cell proliferation, protein phosphorylation, regulation of apoptotic process, regulation of receptor signaling pathway via JAK-STAT, regulation of T cell apoptotic process, response to interleukin-15, response to interleukin-2, response to interleukin-4, response to interleukin-9, T cell homeostasis, tyrosine phosphorylation of STAT protein
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase binding, protein tyrosine kinase activity...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase binding, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytoskeleton, cytosol, endosome, plasma membrane...
cytoskeleton, cytosol, endosome, plasma membrane
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Janus kinase 3
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Kaplan plot for JAK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc