MAP2K6
Entrez ID: 5608
Full name: mitogen-activated protein kinase kinase 6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE7: MEK3
Chromosomal location: 17q24.3
Substructure location: Gatekeeper: 129 A-loop: 196...211, 213...218 G-loop: 59...65 αC-helix: 90...104
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MAP2K6
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role i...
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
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GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, apoptotic process, cardiac muscle contraction, cell cycle arrest, cellular response to sorbitol, DNA damage induced protein phosphorylation, negative regulation of cold-induced thermogenesis, nucleotide-binding oligomerization domai...
activation of MAPK activity, activation of protein kinase activity, apoptotic process, cardiac muscle contraction, cell cycle arrest, cellular response to sorbitol, DNA damage induced protein phosphorylation, negative regulation of cold-induced thermogenesis, nucleotide-binding oligomerization domain containing signaling pathway, ovulation cycle process, positive regulation of apoptotic process, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of prostaglandin secretion, regulation of mitotic cell cycle, response to drug, response to ischemia, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, identical protein binding, MAP kinase kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, identical protein binding, MAP kinase kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytoskeleton, cytosol, nucleoplasm, cytoplasm...
cytoskeleton, cytosol, nucleoplasm, cytoplasm
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mitogen-activated protein kinase kinase 6
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*NOTE: the Kaplan plots were collected from OncoLnc