LIMK1
Entrez ID: 3984
Full name: LIM domain kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: LISK: LIMK
Chromosomal location: 7q11.23
Substructure location: Gatekeeper: 413 A-loop: 477...489, 497...514 G-loop: 344...351 αC-helix: 375...388
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LIMK1
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514,...
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908).
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GO - Biological processes (BP):
actin cytoskeleton organization, Fc-gamma receptor signaling pathway involved in phagocytosis, negative regulation of ubiquitin-protein transferase activity, nervous system development, positive regulation of actin filament bundle assembly, positive regulation of axon extension, positive regulation ...
actin cytoskeleton organization, Fc-gamma receptor signaling pathway involved in phagocytosis, negative regulation of ubiquitin-protein transferase activity, nervous system development, positive regulation of actin filament bundle assembly, positive regulation of axon extension, positive regulation of stress fiber assembly, protein phosphorylation, Rho protein signal transduction, signal transduction
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GO - Molecular function (MF):
ATP binding, heat shock protein binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, heat shock protein binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoskeleton, cytosol, nuclear speck, nucleus, cytoplasm, focal adhesion, lamellipodium, membrane, neuron projection...
cytoskeleton, cytosol, nuclear speck, nucleus, cytoplasm, focal adhesion, lamellipodium, membrane, neuron projection
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LIM domain kinase 1
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A-loop
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αC-helix
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Kaplan plot for LIMK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc